Use Lockbox LIMS to manage your NGS lab through each stage of your sequencing workflows. Lockbox is purpose-built to manage everything from sample preparation, library preparation, adapter ligation, pooling, flow cell design, sample sheet generation, and sequencing runs.
Lockbox LIMS was designed to streamline NGS workflows and ensure complete traceability from sample preparation through to data analysis. Lockbox helps manage plates and sequencing runs and allows users to enter genomic data and use automations to support complex NGS workflows.
Track samples from accession through library preparation and pooling using our CSV import functionality to store sequencing data and automations to ensure quality control standards are maintained.
Manage complex NGS workflows like high-throughput sequencing with our advanced NGS LIMS. Design flow cells, add populated lanes, and generate sample sheets before starting sequencing runs. Even connect your sequencers and instruments with your LIMS using instrument integrations and APIs built to support your lab.
Lockbox LIMS covers the full NGS workflow end-to-end: sample preparation, library preparation, adapter ligation, pooling, flow cell design, sample sheet generation, and the sequencing run. Because laboratories vary in how they run their NGS workflows, Lockbox is built to be configurable enough to support any setup. This includes customizable protocols, plate configurations, automations, and integrations. See our end-to-end NGS workflow overview for details.
NGS labs often run hundreds to thousands of samples per week, with many samples sequenced in parallel on the same flow cell to balance throughput, cost, and data output. Lockbox LIMS is built to support this scale, giving labs the tools to design flow cells, add populated lanes, and generate sample sheets before a run starts — all while maintaining the meticulous tracking needed for data accuracy. Lockbox also automatically creates a Run with its corresponding Flow Cell and Lanes based on the sequencer and flow cell type selected, reducing the manual setup errors that come with high-volume sequencing. Learn more in our end-to-end NGS workflow article.
Yes. Lockbox can generate sequencer sample sheets instantly, auto-populated with data from Sample or Library records — saving lab techs from having to build it manually in Excel. Users can select “Generate Sample Sheet” directly during protocol execution, and Lockbox can even send the sample sheet straight to a lab’s local network or sequencing instrument. Read more in Lockbox LIMS Integrations for NGS Labs.
Lockbox includes pre-configured integrations for common NGS lab needs — Zebra and Dymo label printing, Illumina sample sheet templates, and CSV import/export for data like QC results from a tape station, bioanalyzer, or nanodrop. It can also automate file transfers to and from lab instruments. Beyond the bench, Lockbox connects with business applications for inventory management, order entry, quality control, billing, ERP, electronic signatures (like DocuSign), file storage (Box, MS Teams), and identity management (like Okta). Full details are in our post on NGS lab integrations.
Lockbox LIMS is frequently cited for its flexibility, configurability, and adaptability to changing NGS workflows — protocol versions can be updated as technologies and lab needs evolve, and the system is designed to work with any instrumentation or workflow. Features like the submission portal, broad integration capabilities, and a pre-integrated quality management system all support labs looking to streamline operations without being locked into a rigid, one-size-fits-all system. Read the full comparison in Best LIMS for Next Generation Sequencing (NGS) Labs.
